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The impact of early tumor shrinkage on conversion surgery and the survival in patients with unresectable locally advanced pancreatic cancer
- Source :
- Surgery today. 51(7)
- Publication Year :
- 2020
-
Abstract
- Owing to recent advances in induction chemo(radio)therapy, patients with unresectable locally advanced pancreatic ductal adenocarcinoma (UR-LA PDAC) are sometimes indicated for conversion surgery (CS). However, the predictors for proceeding to CS are unclear. We investigated the predictive factors for CS, especially at the early stage of induction therapy, and evaluated the impact of CS on the survival. We analyzed 49 UR-LA PDAC patients retrospectively and investigated the predictive factors for proceeding to CS, including early tumor shrinkage (ETS). ETS in this study was defined as shrinkage of tumors by ≥ 15% at 8–12 weeks after the induction of treatment. CS was performed in 21 patients (43%). In a multivariate logistic regression analysis, ETS was an independent predictive factor for successfully proceeding to CS (P = 0.046). The median overall survival (OS) was not reached in the CS group but was 17.2 months in the non-CS group (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
Population
030230 surgery
Logistic regression
03 medical and health sciences
0302 clinical medicine
Surgical oncology
medicine
Humans
Stage (cooking)
education
Aged
Retrospective Studies
education.field_of_study
business.industry
Proportional hazards model
Hazard ratio
General Medicine
Induction Chemotherapy
Middle Aged
Prognosis
Conversion to Open Surgery
Confidence interval
Surgery
Pancreatic Neoplasms
Survival Rate
Logistic Models
030220 oncology & carcinogenesis
Female
business
Carcinoma, Pancreatic Ductal
Forecasting
Subjects
Details
- ISSN :
- 14362813
- Volume :
- 51
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Surgery today
- Accession number :
- edsair.doi.dedup.....69798dff8f40bb935b3d175eec2828e0