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Drug interaction between tacrolimus and carbamazepine in a Japanese heart transplant recipient: a case report
- Source :
- The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 28(4)
- Publication Year :
- 2008
-
Abstract
- This article reports changes in tacrolimus (FK506) blood levels connected with carbamazepine (CBZ). A drug interaction between FK506 and CBZ was investigated in a woman, who was in her 40s, who underwent heart transplantation. Pharmacokinetic parameters were measured, including dose and trough blood levels (C(0)), area under the serum concentration-time curve from 0 to 12 hours (AUC(0-12h)), and apparent clearance of oral FK506 (CL/F) for FK506 alone (about 3 months before starting CBZ) and combined with CBZ (11 days and about 3 months after starting CBZ). FK506 C(0) levels were decreased within 7 days of CBZ treatment. FK506 dosing required a 1.3- to 1.4-fold increase to maintain adequate blood levels while taking 200 mg CBZ daily. The AUC(0-12h)/dose 11 days after CBZ treatment was about 50% of the value before CBZ, and was about 70% at 3 months after CBZ treatment. The CL/F at 11 days and about 3 months after starting CBZ treatment was about 2 times higher than before CBZ therapy. FK506 C(0) levels are decreased by CBZ treatment, and blood levels should be closely monitored.
- Subjects :
- Pulmonary and Respiratory Medicine
Adult
Cardiomyopathy, Dilated
Drug-Related Side Effects and Adverse Reactions
medicine.medical_treatment
Pharmacology
Tacrolimus
Pharmacokinetics
Medicine
Humans
Heart transplantation
Transplantation
Protein synthesis inhibitor
business.industry
Carbamazepine
Drug interaction
Calcineurin
Anticonvulsant
Treatment Outcome
Anesthesia
Heart Transplantation
Surgery
Anticonvulsants
Drug Therapy, Combination
Female
Cardiology and Cardiovascular Medicine
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 15573117
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
- Accession number :
- edsair.doi.dedup.....6978703d8fe154e74708d5d98623082f