Back to Search
Start Over
Distinctive cutaneous and systemic features associated with specific antimyositis antibodies in adults with dermatomyositis: a prospective multicentric study of 117 patients
- Source :
- Journal of the European Academy of Dermatology and Venereology, Journal of the European Academy of Dermatology and Venereology, Wiley, 2017, 〈10.1111/jdv.14759〉, Journal of the European Academy of Dermatology and Venereology, Wiley, 2018, 32 (7), pp.1164-1172. ⟨10.1111/jdv.14759⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- BACKGROUND: Identification of myositis-specific autoantibodies (MSAs) for dermatomyositis (DM) could allow the characterization of an antibody-associated clinical phenotype. OBJECTIVE: We sought to define the clinical phenotype of DM and the risk of cancer, interstitial lung disease (ILD) and calcinosis based on MSA. METHODS: A 3.5-year multicentre prospective study of adult DM patients was conducted to determine the clinical phenotype associated with MSAs and the presence of cancer, ILD and calcinosis. RESULTS: MSAs were detected in 47.1% of 117 included patients. Patients with antimelanoma differentiation-associated protein-5 antibodies (13.7%) had significantly more palmar violaceous macules/papules [odds ratio (OR) 9.9], mechanic's hands (OR 8), cutaneous necrosis (OR 3.2), articular involvement (OR 15.2) and a higher risk of ILD (OR 25.3). Patients with antitranscriptional intermediary factor-1 antibodies (11.1%), antinuclear matrix protein-2 antibodies (6.8%) and antiaminoacyl-transfer RNA synthetase (5.1%) had, respectively, significantly more poikiloderma (OR 5.9), calcinosis (OR 9.8) and articular involvement (OR 15.2). Cutaneous necrosis was the only clinical manifestation significantly associated with cancer (OR 3.1). CONCLUSION: Recognition of the adult DM phenotype associated with MSAs would allow more accurate appraisal of the risk of cancer, ILD and calcinosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Interferon-Induced Helicase, IFIH1
Poikiloderma
Dermatology
Hand Dermatoses
Antibodies
Dermatomyositis
Amino Acyl-tRNA Synthetases
030207 dermatology & venereal diseases
03 medical and health sciences
Necrosis
Young Adult
0302 clinical medicine
Calcinosis
Neoplasms
medicine
Humans
Prospective Studies
Prospective cohort study
Aged
Skin
030203 arthritis & rheumatology
Adenosine Triphosphatases
Aged, 80 and over
business.industry
Interstitial lung disease
Autoantibody
Cancer
Odds ratio
Middle Aged
medicine.disease
3. Good health
DNA-Binding Proteins
Infectious Diseases
Phenotype
Female
Joint Diseases
business
Lung Diseases, Interstitial
[ SDV.MHEP.DERM ] Life Sciences [q-bio]/Human health and pathology/Dermatology
[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 09269959 and 14683083
- Database :
- OpenAIRE
- Journal :
- Journal of the European Academy of Dermatology and Venereology, Journal of the European Academy of Dermatology and Venereology, Wiley, 2017, 〈10.1111/jdv.14759〉, Journal of the European Academy of Dermatology and Venereology, Wiley, 2018, 32 (7), pp.1164-1172. ⟨10.1111/jdv.14759⟩
- Accession number :
- edsair.doi.dedup.....696bdb5f70a9c1ca3b38b404dae6c81b