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Induction of glandular stomach cancers in Helicobacter pylori-infected Mongolian gerbils by 1-nitrosoindole-3-acetonitrile
- Source :
- International journal of cancer. 130(2)
- Publication Year :
- 2010
-
Abstract
- Helicobacter pylori (H. pylori) infection and high intake of various traditional salt-preserved foods are regarded as risk factors for human gastric cancer. We previously reported that Chinese cabbage contains indole compounds, such as indole-3-acetonitrile, a mutagen precursor. 1-Nitrosoindole-3-acetonitrile (NIAN), formed by the treatment of indole-3-acetonitrile with nitrite under acidic conditions, shows direct-acting mutagenicity. In the present study, NIAN administration by gavage to Mongolian gerbils (MGs) at the dose of 100 mg/kg two times a week resulted in three adduct spots (1.6 adducts/10(8) nucleotides in total), detected in DNA samples from the glandular stomach by (32) P-postlabeling methods. Treatment with six consecutive doses of 100 mg/kg of NIAN, two times a week for 3 weeks, induced well-and moderately-differentiated glandular stomach adenocarcinomas in the MGs at the incidence of 31% under H. pylori infection at 54-104 weeks. Such lesions were not induced in MGs given broth alone, broth + NIAN or infection with H. pylori alone. Thus, endogenous carcinogens formed from nitrosation of indole compounds could be critical risk factors for human gastric cancer development under the influence of H. pylori infection.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Pathology
Acetonitriles
Mutagen
Endogeny
Adenocarcinoma
medicine.disease_cause
Gastroenterology
Drug Administration Schedule
Helicobacter Infections
chemistry.chemical_compound
DNA Adducts
Stomach Neoplasms
Internal medicine
medicine
Animals
Nitrite
Carcinogen
Indole test
Cocarcinogenesis
biology
Helicobacter pylori
business.industry
Cancer
medicine.disease
biology.organism_classification
Specific Pathogen-Free Organisms
Cell Transformation, Neoplastic
Oncology
chemistry
Gastritis
Nitrosation
business
Gerbillinae
Subjects
Details
- ISSN :
- 10970215
- Volume :
- 130
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of cancer
- Accession number :
- edsair.doi.dedup.....694ef199a6dcf5ac3ca8e16c558c54ea