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Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase
- Source :
- Bioorganic & Medicinal Chemistry Letters. 15:3519-3523
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- A series of dianilinopyrimidineureas demonstrate potency as VEGFR2 kinase inhibitors.
- Subjects :
- Isostere
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Structure-Activity Relationship
Drug Discovery
Urea
Structure–activity relationship
Potency
Enzyme Inhibitors
Molecular Biology
Aniline Compounds
biology
Chemistry
Kinase
Organic Chemistry
Stereoisomerism
Kinase insert domain receptor
HIV Protease Inhibitors
Protein-Tyrosine Kinases
respiratory system
Vascular Endothelial Growth Factor Receptor-2
Pyrimidines
Enzyme inhibitor
cardiovascular system
biology.protein
Molecular Medicine
Signal transduction
Tyrosine kinase
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....6946bbbc0f2a909c27b5a7ff105ca1eb