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Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?
- Source :
- Journal of Mammary Gland Biology and Neoplasia
- Publication Year :
- 2021
- Publisher :
- Springer US, 2021.
-
Abstract
- Regions of high mammographic density (MD) in the breast are characterised by a proteoglycan (PG)-rich fibrous stroma, where PGs mediate aligned collagen fibrils to control tissue stiffness and hence the response to mechanical forces. Literature is accumulating to support the notion that mechanical stiffness may drive PG synthesis in the breast contributing to MD. We review emerging patterns in MD and other biological settings, of a positive feedback cycle of force promoting PG synthesis, such as in articular cartilage, due to increased pressure on weight bearing joints. Furthermore, we present evidence to suggest a pro-tumorigenic effect of increased mechanical force on epithelial cells in contexts where PG-mediated, aligned collagen fibrous tissue abounds, with implications for breast cancer development attributable to high MD. Finally, we summarise means through which this positive feedback mechanism of PG synthesis may be intercepted to reduce mechanical force within tissues and thus reduce disease burden.
- Subjects :
- Cancer Research
Carcinogenesis
Breast Neoplasms
medicine.disease_cause
Fibrous stroma
Mechanical pressure
Breast cancer
medicine
Pressure
Humans
Breast
Mechanical stiffness
Mammographic density
Positive feedback
Breast Density
Review Paper
biology
MAMMOGRAPHIC DENSITY
medicine.disease
Cell biology
Biomechanical Phenomena
Extracellular Matrix
Oncology
Proteoglycan
biology.protein
Proteoglycans
Female
Collagen
Tissue stiffness
Biomarkers
Mammography
Subjects
Details
- Language :
- English
- ISSN :
- 15737039 and 10833021
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Mammary Gland Biology and Neoplasia
- Accession number :
- edsair.doi.dedup.....694587c3492333bd69ea0bdcd857adc7