The Clinical Assay of a New Fungicide, P-594 (2-Nitro-2-Bromo-1-Methoxy-1-Phenylpropane)1

The clinical evaluation of a fungicide is difficult. The tendency of fungous organisms to remain viable but go into resting states confuses the term “cure. With those problems in mind a project was designed to assay a new fungicide, 2-nitro-2-bromo-l-methoxy-l-phenylpropane. This compound shall henceforth be known by its commercial designation, P-594. f By the time that P-594 was brought to our attention the facts were already established that oral toxicity of this material was negligible and that therapeutic concentrations of the fungicide in a water soluble ointment base were not primary irritants for the skin of white rabbits (1). Moderate intraperitoneal toxicity for white mice was noted, the LDOO range being 195 ± 38 mg./kg. Also established were the facts that this material showed in vitro fungistasis for T. men-tagrophytes in a concentration of 1 mcg./ml. and for C. albicans in a concentration of 30 Mg./ml.