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Genome-Wide Association Study of Bone Mineral Density in Korean Men
- Source :
- Genomics & Informatics, Vol 14, Iss 2, Pp 62-68 (2016), Genomics & Informatics
- Publication Year :
- 2016
- Publisher :
- Korea Genome Organization, 2016.
-
Abstract
- Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. Bone mineral density (BMD), a highly heritable trait, has been proven a useful diagnostic factor in predicting fracture. Because medical information is lacking about male osteoporotic genetics, we conducted a genome-wide association study of BMD in Korean men. With 1,176 participants, we analyzed 4,414,664 single nucleotide polymorphisms (SNPs) after genomic imputation, and identified five SNPs and three loci correlated with bone density and strength. Multivariate linear regression models were applied to adjust for age and body mass index interference. Rs17124500 (p = 6.42 × 10(-7)), rs34594869 (p = 6.53 × 10(-7)) and rs17124504 (p = 6.53 × 10(-7)) in 14q31.3 and rs140155614 (p = 8.64 × 10(-7)) in 15q25.1 were significantly associated with lumbar spine BMD (LS-BMD), while rs111822233 (p = 6.35 × 10(-7)) was linked with the femur total BMD (FT-BMD). Additionally, we analyzed the relationship between BMD and five genes previously identified in Korean men. Rs61382873 (p = 0.0009) in LRP5, rs9567003 (p = 0.0033) in TNFSF11 and rs9935828 (p = 0.0248) in FOXL1 were observed for LS-BMD. Furthermore, rs33997547 (p = 0.0057) in ZBTB and rs1664496 (p = 0.0012) in MEF2C were found to influence FT-BMD and rs61769193 (p = 0.0114) in ZBTB to influence femur neck BMD. We identified five SNPs and three genomic regions, associated with BMD. The significance of our results lies in the discovery of new loci, while also affirming a previously significant locus, as potential osteoporotic factors in the Korean male population.
- Subjects :
- 0301 basic medicine
musculoskeletal diseases
medicine.medical_specialty
Bone density
Koreans
lcsh:QH426-470
Osteoporosis
men
Health Informatics
Single-nucleotide polymorphism
Locus (genetics)
Genome-wide association study
Biology
03 medical and health sciences
single nucleotide polymorphisms
Internal medicine
Genetics
medicine
Femur
Ecology, Evolution, Behavior and Systematics
Bone mineral
genome-wide association study
bone density
medicine.disease
musculoskeletal system
lcsh:Genetics
030104 developmental biology
Endocrinology
Original Article
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 22340742
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Genomics & Informatics
- Accession number :
- edsair.doi.dedup.....693f6d5b8d65e5a2c5907be538922bac