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Clinical Burden of Modified Glasgow Prognostic Scale in Colorectal Cancer
- Source :
- Anticancer research. 38(3)
- Publication Year :
- 2017
-
Abstract
- Background/aim This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). Patients and methods A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. Results High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Conclusion Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.
- Subjects :
- 0301 basic medicine
Oncology
Male
Cancer Research
medicine.medical_specialty
Prognostic factor
Colorectal cancer
Kaplan-Meier Estimate
Uicc stage
Prognostic score
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Biomarkers, Tumor
Humans
Stage (cooking)
Serum Albumin
Aged
Neoplasm Staging
Aged, 80 and over
030109 nutrition & dietetics
business.industry
Disease progression
General Medicine
Middle Aged
medicine.disease
Prognosis
Carcinoembryonic Antigen
C-Reactive Protein
030220 oncology & carcinogenesis
Sarcopenia
Multivariate Analysis
Biomarker (medicine)
Female
business
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 17917530
- Volume :
- 38
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.doi.dedup.....6934bd6ebd755cabd33022c930a41aab