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Clinical Burden of Modified Glasgow Prognostic Scale in Colorectal Cancer

Authors :
Yoshinaga Okugawa
Takeshi Yokoe
Toshimitsu Araki
Asahi Hishida
Chikao Miki
Hiromi Yasuda
Masato Kusunoki
Minako Kobayashi
Susumu Saigusa
Koji Tanaka
Yuji Toiyama
Motoyoshi Tanaka
Yasuhiro Inoue
Donald C. McMillan
Yumiko Shirai
Hiroyuki Fujikawa
Junichiro Hiro
Source :
Anticancer research. 38(3)
Publication Year :
2017

Abstract

Background/aim This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). Patients and methods A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. Results High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Conclusion Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.

Details

ISSN :
17917530
Volume :
38
Issue :
3
Database :
OpenAIRE
Journal :
Anticancer research
Accession number :
edsair.doi.dedup.....6934bd6ebd755cabd33022c930a41aab