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The effect of continuous positive airway pressure on pulmonary function may depend on the basal level of forced expiratory volume in 1 second
- Publication Year :
- 2018
-
Abstract
- Background The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), also referred to as overlap syndrome (OS), is associated with a high rate of morbidity, COPD exacerbations and mortality. Treatment with continuous positive airway pressure (CPAP) has proven to significantly decrease the rate of these complications. However, data concerning the effect of CPAP on pulmonary function are scarce and conflicting. The aim of our study was to evaluate the effect of 1 year of CPAP treatment on arterial blood gases (ABGs) and pulmonary function tests in patients with OS and its potential relationship with the baseline severity of airway obstruction. A secondary aim was to search for predictors of changes in the evaluated parameters. Methods A retrospective study on a cohort of 92 patients (74 males) discharged from the Pulmonary Rehabilitation Unit of the Istituti Clinici Scientifici Maugeri in Pavia (Italy) from January 2013 to January 2016, with a diagnosis of OS and a prescription of CPAP, was conducted. Collected data at discharge were compared with 1-year follow-up data. Results After 1 year of CPAP, we observed the following: (I) a significant improvement in ABGs in all patients [median pO2 65.0 (59.0-70.0) vs. 71 (64.8-77.1) mmHg, pCO2 39.8 (36.2-43.5) vs. 38.3 (32.3-44.2) at baseline and after 1 year respectively, P
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
medicine.medical_treatment
Population
Chronic obstructive pulmonary disease (COPD)
Obstructive sleep apnea (OSA)
030204 cardiovascular system & hematology
Pulmonary function testing
Continuous positive airway pressure (CPAP)
Overlap syndrome (OS)
Pulmonary function tests
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Respiratory function
Pulmonary rehabilitation
Continuous positive airway pressure
education
education.field_of_study
COPD
business.industry
Airway obstruction
medicine.disease
respiratory tract diseases
Obstructive sleep apnea
030228 respiratory system
Cardiology
Original Article
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6931d0f4205e21341ceee2ce884189de