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Vulvar intraepithelial neoplasia grade 3 associated with Behçet’s disease
- Source :
- BMC Research Notes, BMC Research Notes, Vol. 9, No 1 (2016) P. 172
- Publisher :
- Springer Nature
-
Abstract
- Background Little information is available regarding the association between vulvar intraepithelial neoplasia grade 3 (VIN3) and Behçet’s disease (BD). We report here concomitant VIN3 and genital ulcers in a patient with BD. Case A 44-year-old Caucasian woman with a history of BD, which had been evolving for 6 years, presented with ulcerated and papillomatous lesions on the vulva. Biopsies revealed a multifocal VIN3 positive for high-risk human papillomavirus (HPV) 33. Multiple biopsies were performed to exclude invasive cancer and VIN3 was treated with laser vaporization. Conclusion We report clinical and anatomopathological features of a rare case of multifocal, high-risk, HPV-related VIN3. We also discuss the possible pathogenesis in the context of BD, featuring chronic ulceration and intrinsic or treatment-induced immunosuppression.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Human papillomavirus
Case Report
Disease
Behcet's disease
ddc:616.07
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Behçet’s disease
0302 clinical medicine
Vulvar intraepithelial neoplasia
medicine
Humans
Sex organ
Vulvar neoplasm
Gynecology
Medicine(all)
ddc:618
Behçet's disease
Genital ulceration
Vulvar Neoplasms
business.industry
Biochemistry, Genetics and Molecular Biology(all)
Carcinoma in situ
Behcet Syndrome
General Medicine
medicine.disease
Dermatology
030104 developmental biology
030220 oncology & carcinogenesis
Concomitant
Female
Neoplasm Grading
business
Carcinoma in Situ
Subjects
Details
- Language :
- English
- ISSN :
- 17560500
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Research Notes
- Accession number :
- edsair.doi.dedup.....691d83204988e160bc6202344ccc695a
- Full Text :
- https://doi.org/10.1186/s13104-016-1985-7