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Global characteristics of childhood acute promyelocytic leukemia
- Source :
- Blood Reviews. 29:101-125
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Acute promyelocytic leukemia (APL) comprises approximately 5–10% of childhood acute myeloid leukemia (AML) cases in the US. While variation in this percentage among other populations was noted previously, global patterns of childhood APL have not been thoroughly characterized. In this comprehensive review of childhood APL, we examined its geographic pattern and the potential contribution of environmental factors to observed variation. In 142 studies (spanning >60 countries) identified, variation was apparent—de novo APL represented from 2% (Switzerland) to >50% (Nicaragua) of childhood AML in different geographic regions. Because a limited number of previous studies addressed specific environmental exposures that potentially underlie childhood APL development, we gathered 28 childhood cases of therapy-related APL, which exemplified associations between prior exposures to chemotherapeutic drugs/radiation and APL diagnosis. Future population-based studies examining childhood APL patterns and the potential association with specific environmental exposures and other risk factors are needed.
- Subjects :
- Acute promyelocytic leukemia
Pediatrics
medicine.medical_specialty
Population
Article
Cytogenetics
Leukemia, Promyelocytic, Acute
Risk Factors
immune system diseases
Acute lymphocytic leukemia
medicine
Humans
Geography, Medical
Child
education
neoplasms
Childhood Acute Promyelocytic Leukemia
education.field_of_study
business.industry
Childhood Acute Myeloid Leukemia
Environmental Exposure
Hematology
Odds ratio
Environmental exposure
Prognosis
medicine.disease
Leukemia
Oncology
business
Subjects
Details
- ISSN :
- 0268960X
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Blood Reviews
- Accession number :
- edsair.doi.dedup.....6912fdafad4de2698c66c1975203771d