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Efficacy and safety of glecaprevir and pibrentasvir treatment for 8 or 12 weeks in patients with recurrent hepatitis C after liver transplantation: a Japanese multicenter experience
- Source :
- Journal of gastroenterology. 54(7)
- Publication Year :
- 2018
-
Abstract
- Efficacy of 8-week regimen with direct-acting antivirals (DAA) for patients with hepatitis C after liver transplantation has not been clarified. This study aimed to clarify the efficacy and safety of glecaprevir and pibrentasvir therapy for 8 and 12 weeks in Japanese patients with recurrent hepatitis C after liver transplantation. A cohort study of liver transplant recipients with recurrent hepatitis C treated with glecaprevir (300 mg/day) and pibrentasvir (120 mg/day) was performed at nine liver transplant centers in Japan. Twenty-five patients with hepatitis C after liver transplantation were treated with glecaprevir and pibrentasvir. Twenty-four patients completed the treatment protocol; treatment was discontinued in one patient who had nausea at 3 days after the initiation of treatment. All the 24 patients who completed the 8- or 12-week treatment protocol achieved a sustained virological response 12 weeks after completion of treatment (SVR12). The SVR12 rates in patients with HCV genotype 1 and 2 were 100% (21 of 21 patients) and 75% (3 of 4 patients), respectively. All patients with prior DAA therapy failure (n = 6), jaundice (n = 4), and liver cirrhosis (n = 4) achieved SVR12. Seven of 8 patients (88%) with severe renal impairment achieved SVR12. Adverse events occurred in 6 of 25 patients (24%), including serious adverse events in 2 patients (8%). Treatment-related adverse events were nausea, pruritus, and mild renal dysfunction. Eight- or 12-week regimen of glecaprevir and pibrentasvir is efficacious and safe in patients with recurrent HCV infection after liver transplantation, even in difficult-to-treat populations, including patients with severe renal impairment, prior DAA experience, liver cirrhosis, or jaundice after liver transplantation.
- Subjects :
- Male
medicine.medical_specialty
Cirrhosis
Pyrrolidines
Genotype
Sustained Virologic Response
medicine.medical_treatment
Hepacivirus
Liver transplantation
Gastroenterology
Antiviral Agents
Cohort Studies
Japan
Recurrence
Internal medicine
Quinoxalines
medicine
Humans
Aged
Sulfonamides
business.industry
Hepatitis C
Glecaprevir
Jaundice
Hepatology
Hepatitis C, Chronic
Middle Aged
medicine.disease
Pibrentasvir
Liver Transplantation
Regimen
Drug Combinations
Benzimidazoles
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 14355922
- Volume :
- 54
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....6911087f4ff8025f9091e3bedbf0b006