Impact of Cold Ischemia Time on Outcomes of Liver Transplantation: A Single Center Experience

Significant geographic disparities exist in access to liver transplantation and consequently the current liver allocation system is being challenged. We sought to describe our unique experience with using organs with long cold ischemia times from the largest donation service area.From 2009-2014 we performed 350 liver transplants. 167 (48%) had a cold ischemia time8 hours, 134 (38%) between 8 and 12 hours, and 49 (14%) greater than 12 hours.Early allograft dysfunction was observed more commonly with increasing cold ischemia times. 53% of the recipients in the12 h group had early allograft dysfunction compared to 28% in the 8-12 h group, and 18% in the8 h group (P0.001). We found no correlation between early allograft dysfunction and allograft or patient survival. One-year liver allograft survival was 92%, 94%, 87%, three-year graft survival was 82%, 89%, and 87%, and five-year graft survival was 82%, 89%, and 79% in the8 h, 8-12 h, and12 h cold ischemia time groups, respectively. One-year patient survival was 95%, 94%, and 92% and five-year patient survival was 90%, 89%, and 83% in the8 h, 8-12 h, and12 h cold ischemia time groups, respectively. Both unadjusted and multivariate Cox regression analyses indicated no statistically significant associations between cold ischemia time and graft or patient survival.In conclusion, the prolonged cold ischemia time led to early allograft dysfunction but did not have a deleterious association with graft or patient survival.