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Relation Between Plasma Adiponectin, High-Sensitivity C-Reactive Protein, and Coronary Plaque Components in Patients With Acute Coronary Syndrome
- Source :
- The American Journal of Cardiology. 101:1-7
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- The present study investigated the relation between plasma high-sensitivity C-reactive protein (hs-CRP) and adiponectin and coronary plaque components in patients with acute coronary syndrome (ACS). Previous studies showed a pivotal role of inflammation in the progression of atherosclerosis and the prognostic value of several biomarkers. However, relations among inflammatory biomarkers and plaque characteristics were unknown. Ninety-three culprit plaques (ACS n = 50, non-ACS n = 43) and 56 nonculprit plaques (ACS n = 28, non-ACS n = 28) were analyzed using Virtual Histology intravascular ultrasound to examine relations among plasma hs-CRP, adiponectin, and ratios of each coronary plaque component. Plasma adiponectin was significantly lower and plasma hs-CRP was significantly higher in patients with than without ACS. Culprit plaques in patients with ACS had greater amounts of necrotic core plaque than those in patients without ACS. There was an inverse relation between serum hs-CRP and adiponectin with regard to necrotic core ratio in both culprit and nonculprit lesions in patients with ACS, but not those without ACS. In conclusion, increased plasma hs-CRP and hypoadiponectinemia might be related to the progression of ACS.
- Subjects :
- Adult
Male
Acute coronary syndrome
medicine.medical_specialty
Inflammation
Coronary Artery Disease
Plasma adiponectin
Culprit
Coronary plaque
Internal medicine
medicine
Humans
In patient
Acute Coronary Syndrome
Ultrasonography, Interventional
Aged
Aged, 80 and over
Ventricular Remodeling
Adiponectin
biology
business.industry
C-reactive protein
Middle Aged
medicine.disease
Coronary Vessels
C-Reactive Protein
Case-Control Studies
biology.protein
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- The American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....690442e1487c44fc394d0dc86810367f
- Full Text :
- https://doi.org/10.1016/j.amjcard.2007.07.041