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Safety and efficacy of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C in patients aged 65 years or older
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 1, p e0208506 (2019)
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- Finding safe and effective treatments for chronic hepatitis C virus (HCV) infection in the elderly is of clinical interest given the comorbidities and associated polypharmacy in this population. However, the number of patients older than age 65 years enrolled into clinical trials of anti-HCV medications generally have been limited and thus reaching meaningful conclusions for this demographic has been difficult. Glecaprevir/pibrentasvir is a once-daily, all-oral, ribavirin-free, pangenotypic direct-acting antiviral (DAA) combination therapy that has demonstrated high sustained virologic response rates at post-treatment week 12 (SVR12) and a favorable safety profile in patients with chronic HCV infection. This analysis evaluated the safety and efficacy of glecaprevir/pibrentasvir in patients aged ≥65 years. Data were pooled for treatment-naïve and -experienced patients with chronic HCV genotype (GT) 1-6 infections who received glecaprevir/pibrentasvir for 8, 12, or 16 weeks in 9 Phase 2 and 3 trials. SVR12 and adverse events (AEs) were evaluated for patients aged ≥65 versus
- Subjects :
- RNA viruses
Cyclopropanes
Male
Aminoisobutyric Acids
Pyrrolidines
Hepacivirus
Kidney
Geriatric Depression
Elderly
0302 clinical medicine
Medicine and Health Sciences
030212 general & internal medicine
Pathology and laboratory medicine
Geriatric Nephrology
Geriatrics
Sulfonamides
education.field_of_study
Multidisciplinary
Hepatitis C virus
Depression
Liver Diseases
Hepatitis C
Medical microbiology
Pibrentasvir
Treatment Outcome
Cirrhosis
Nephrology
Viruses
Medicine
Drug Therapy, Combination
Female
030211 gastroenterology & hepatology
Pathogens
Research Article
medicine.medical_specialty
Drug Research and Development
Proline
Science
Lactams, Macrocyclic
Geriatric Psychiatry
Population
Gastroenterology and Hepatology
Research and Analysis Methods
Microbiology
03 medical and health sciences
Leucine
Quinoxalines
Internal medicine
Mental Health and Psychiatry
medicine
Humans
Clinical Trials
education
Adverse effect
Aged
Pharmacology
Polypharmacy
Biology and life sciences
Flaviviruses
Mood Disorders
business.industry
Organisms
Viral pathogens
Glecaprevir
Hepatitis C, Chronic
medicine.disease
Fibrosis
Hepatitis viruses
Microbial pathogens
Discontinuation
Age Groups
People and Places
Population Groupings
Benzimidazoles
Clinical Medicine
Safety Studies
business
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....68fab6405ff47de1ecffa79f83a89d47