Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis

// Yong Li 1, * , Yi-Hong Liu 1, * , Xian Chen 1 , Yan-Juan Zhu 1 , Hai-Bo Zhang 1 , Yan Li 1 , Jian-Ping Bai 1 , Li-Rong Liu 1 , Yan-Chun Qu 1 and Xin Qu 1 1 Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong, China * Yong Li and Yi-Hong Liu contributed equally to this work Correspondence to: Hai-Bo Zhang, email: bubu400865@sohu.com Keywords: long non-coding RNAs, HULC, cancer, overall survival Received: April 18, 2017 Accepted: May 03, 2017 Published: June 13, 2017 SUMMARY Some studies investigated the association between highly up-regulated in liver cancer (HULC) and the overall survival (OS) of cancer. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to determine the association between HULC and the OS of cancer. A comprehensive online search was conducted on Online electronic databases (PubMed, EMBASE, and Wanfang database) from the earliest date to Aug 30, 2016. The strength of the association was calculated with the HRs and respective 95% CIs. The expression of HULC was significantly associated with OS of cancers (HR = 2.12; 95% CI 1.61 – 2.79; P