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Beyond intima-media-thickness: Analysis of the carotid intima-media-roughness in a paediatric population
- Source :
- Atherosclerosis. 251:164-169
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background and aims: Subclinical atherosclerosis assessed by sonographic intima-media-thickness measurement of the carotid artery (cIMT) is considered to be an early precursor of cardiovascular disease already in childhood. Structural analysis of the carotid intimal layer (carotid intima-media-roughness, cIMR) improves cardiovascular risk profiling for the adult patient and has been shown to be increased also in paediatric patients with elevated cardiovascular risk. To date, normal values for the paediatric age are lacking. Thus, we present normative data for a paediatric age group. Methods: 602 healthy German school children (age 8-18 y) were studied, and cIMT and cIMR calculated;reference values were given for three age groups (group 1: 8-10.99 years;group 2: 11-13.99 years;group 3: 14-17.99 years). Results: cIMT values were: 0.48 +/- 0.03 mm for girls and boys in age group 1, 0.49 +/- 0.03 mm for girls and boys in age group 2;and 0.45 +/- 0.03 mm for girls and 0.49 +/- 0.03 mm for boys in age group 3;cIMR was 0.04 +/- 0.01 mm for both sexes in age group 1 and 3;while in age group 2, both sexes showed a cIMR of 0.03 +/- 0.01 mm. Physical fitness was significantly negatively correlated with cIMR (r = -0.212, p < 0.0001) and a strong predictor for cIMR increase. Conclusions: The normative data of cIMR for a paediatric age group presented here allow for the identification of patients at elevated cardiovascular risk. By including cIMR as surface analysis of the arterial wall, the individual risk stratification may be improved compared to thickness-analysis of the Intima-Media-Layer (cIMT) also at a paediatric age. (C) 2016 Published by ELSEVIER.
- Subjects :
- Male
Risk profiling
medicine.medical_specialty
Adolescent
Carotid Artery, Common
Physical fitness
Cardiology
030204 cardiovascular system & hematology
Individual risk
Carotid Intima-Media Thickness
Risk Assessment
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Age groups
Reference Values
Risk Factors
Germany
Internal medicine
medicine
Humans
030212 general & internal medicine
Child
Ultrasonography
business.industry
Healthy Volunteers
Surgery
Cross-Sectional Studies
Intima-media thickness
Reference values
Subclinical atherosclerosis
Disease Progression
Female
Cardiology and Cardiovascular Medicine
business
Paediatric population
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 251
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....68f0311d9b4c5d27ad8430adecba5a2a