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Co-infection in patients with hypoxemic pneumonia due to COVID-19 in Reunion Island
- Source :
- Medicine
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- This study aimed to evaluate the incidence of co-infection with different types of pathogens in patients with hypoxemic pneumonia due to coronavirus disease 2019 (COVID-19) in Reunion Island.This observational study using a prospectively collected database of hypoxemic pneumonia due to COVID-19 cases was conducted at Felix Guyon University Hospital in Reunion Island, France.Between 18 March 2020 and 15 April 2020, 156 patients were admitted to our hospital for COVID-19. A total of 36 patients had hypoxemic pneumonia (23.1%) due to COVID-19. Thirty of these cases (83.3%) were imported by travelers returning mainly from metropolitan France and Spain. Patients were screened for co-infection with other pathogens at admission: 31 (86.1%) by multiplex polymerase chain reaction (PCR) and 16 (44.4%) by cytobacteriological examination of sputum culture. Five patients (13.9%) were found to have co-infection: 1 with influenza virus A H1N1 (pdm09) associated with Branhamella catarrhalis, 1 with Streptococcus pneumoniae associated with Haemophilus influenzae, 1 with Human Coronavirus 229E, 1 with Rhinovirus, and 1 with methicillin-susceptible Staphylococcus aureus. Patients with co-infection had higher D-dimer levels than those without co-infection (1.36 [1.34-2.36] µg/mL vs 0.63 [0.51-1.12] µg/mL, Pâ=â.05).The incidence of co-infection in our cohort was higher than expected (13.9%). Three co-infections (with influenza virus A(H1N1) pdm09, Streptococcus pneumoniae, and Staphylococcus aureus) required specific treatment. Patients with hypoxemic pneumonia due to COVID-19 should be screened for co-infection using respiratory cultures or multiplex PCR. Whilst our study has a number of limitations, the results from our study suggest that in the absence of screening, patients should be commenced on treatment for co-infection in the presence of an elevated D-dimer.
- Subjects :
- Adult
Male
Staphylococcus aureus
medicine.medical_specialty
Observational Study
medicine.disease_cause
Haemophilus influenzae
Sputum culture
coronavirus disease 2019
03 medical and health sciences
co-infection
0302 clinical medicine
Internal medicine
Streptococcus pneumoniae
medicine
Humans
030212 general & internal medicine
Hypoxia
Retrospective Studies
medicine.diagnostic_test
SARS-CoV-2
Coinfection
business.industry
Incidence (epidemiology)
COVID-19
Retrospective cohort study
Pneumonia
General Medicine
Middle Aged
medicine.disease
030220 oncology & carcinogenesis
Female
France
Rhinovirus
influenza
business
Research Article
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....68eb8eed0ca6abd52000ec302affae69