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Pathobiology of hepatitis E: lessons learned from primate models
- Source :
- Emerging Microbes & Infections
- Publication Year :
- 2013
- Publisher :
- Nature Publishing Group, 2013.
-
Abstract
- Like the other hepatitis viruses, hepatitis E virus (HEV) has been difficult to study because of limitations in cell culture systems and small animal models. Much of what we know has come from epidemiological studies in developing countries and, more recently, in industrialized countries. However, the epidemiology is very different in these two settings: hepatitis E in developing countries is epidemic as well as sporadic, principally water-borne, most likely to cause disease in older children and young adults and relatively severe, especially in pregnant women; in industrialized countries the disease is sporadic, principally food-borne, most common in the elderly and probably associated with mostly inapparent infections. These differences are believed to be genotypically determined. To examine the biological parameters of hepatitis E, we have studied HEV infections in nonhuman primates, which are surrogates of man. Infections with HEV genotypes 1–3 were compared in rhesus and cynomolgus macaques and chimpanzees. In general, the biological characteristics of the different HEV genotypes mirrored their epidemiological characteristics.
- Subjects :
- medicine.medical_specialty
Epidemiology
nonhuman primates
Immunology
Developing country
host range
Disease
Biology
Bioinformatics
medicine.disease_cause
Microbiology
Hepatitis E virus
genotypes
Virology
Drug Discovery
Genotype
medicine
Young adult
General Medicine
Hepatitis E
medicine.disease
virulence
Infectious Diseases
HEV
Parasitology
Original Article
Developed country
Subjects
Details
- Language :
- English
- ISSN :
- 22221751
- Volume :
- 2
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Emerging Microbes & Infections
- Accession number :
- edsair.doi.dedup.....68e44f09df7acfc6df814b9b3f492b7b