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Conditioning on Certain Random Events Associated with Statistical Variability in PK/PD
- Source :
- Journal of Pharmacokinetics and Pharmacodynamics. 32:213-243
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- In PK/PD data analysis, statistical models involving random variables are developed. At times an analysis can be carried out by conditioning on certain random events involving these variables. This paper attempts to clarify issues regarding conditioning. In particular, conditioning is examined as it relates to a number of disparate practical matters: missing covariate values, dose titration, BQL data, "no change from baseline" data, and the use of a truncated intraindividual probability distribution for PK observations.
- Subjects :
- Pharmacology
Models, Statistical
Dose-Response Relationship, Drug
Dose titration
Statistical model
Truncated distribution
Pharmaceutical Preparations
Statistics
Covariate
Apgar Score
Econometrics
Humans
Probability distribution
Conditioning
Pharmacokinetics
Random variable
Algorithms
Software
PK/PD models
Mathematics
Subjects
Details
- ISSN :
- 15738744 and 1567567X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacokinetics and Pharmacodynamics
- Accession number :
- edsair.doi.dedup.....68dd63513c81251554df4f03dbfc2763