Prebiotic chemistry

Prebiotic chemistry has dominated the origins of life (OoL) field to such an extent that often these terms have been used interchangeably. While prebiotic chemistry has benefited from cross-seeding with other disciplines (e.g., biochemistry, biophysics, computational sciences, geosciences), the OoL problem is still primarily a chemical one. The range of possible non-enzymatic pathways provisioning important biomolecules is becoming clearer, and the problem can now be cast in terms of understanding how the constructive interplay between such pathways is underlying the mechanisms controlling their self-organization into systems. Those systems must be capable of producing their constituent parts and reproducing as a result, with a degree of maintaining and transferring their information content. This chapter provides a concise historical overview of the research field, presents a comprehensive panorama of the possible synthesis pathways for each biomolecular domain, discusses the homochirality conundrum, argues a case for experimentation using non-classical materials, and models, and finally considers current and future trends.