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Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography
- Source :
- Lyng, M B, Kodahl, A R, Binder, H & Ditzel, H J 2016, ' Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography ', Molecular Oncology, vol. 10, no. 10, pp. 1621–1626 . https://doi.org/10.1016/j.molonc.2016.10.004
- Publication Year :
- 2016
-
Abstract
- Mammography is the predominant screening method for early detection of breast cancer, but has limitations and could be rendered more accurate by combination with a blood-based biomarker profile. Circulating microRNAs (miRNAs) are increasingly recognized as strong biomarkers, and we previously developed a 9-miRNA profile using serum and LNA-based qPCR that effectively stratified patients with early stage breast cancer vs. healthy women. To further develop the test into routine clinical practice, we collected serum of women examined by clinical mammography (N = 197) according to standard operational procedures (SOPs) of the Danish Cancer Biobank. The performance of the circulating 9-miRNA profile was analyzed in 116 of these women, including 36 with breast cancer (aged 50-74), following a standardized protocol that mimicked a routine clinical set-up. We confirmed that the profile is significantly different between women with breast cancer and controls (p-value
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Early detection
Breast Neoplasms
Cancer Biobank
Disease
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
microRNA
Biomarkers, Tumor
Genetics
medicine
Humans
Mammography
Breast
Prospective Studies
Stage (cooking)
Research Articles
Aged
Gynecology
medicine.diagnostic_test
business.industry
Gene Expression Profiling
General Medicine
Middle Aged
Prognosis
medicine.disease
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Cohort
Molecular Medicine
Biomarker (medicine)
Female
Sample collection
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Lyng, M B, Kodahl, A R, Binder, H & Ditzel, H J 2016, ' Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography ', Molecular Oncology, vol. 10, no. 10, pp. 1621–1626 . https://doi.org/10.1016/j.molonc.2016.10.004
- Accession number :
- edsair.doi.dedup.....68da18353fd69996a76ba74f5f8e91ff