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Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease
- Source :
- The American Journal of the Medical Sciences. 354:379-387
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Controversy remains regarding the efficacy of folic acid supplementation in reducing the risk of stroke. This study aimed to evaluate the effect of folic acid supplementation on stroke prevention in patients with cardiovascular disease (CVD). Materials and Methods We searched the PubMed, EMBASE and Cochrane Library databases through October 2016 to identify randomized clinical trials of folic acid supplementation to prevent stroke in patients with CVD. Relative risks (RRs) with 95% CIs were used to examine the association between folic acid supplementation and the risk of stroke with a fixed-effect model. Stratified analyses were performed according to modifiers that may affect the efficacy of folic acid supplementation. Results Eleven studies with a total of 65,790 participants were included. Folic acid supplementation was associated with a significant benefit in reducing the risk of stroke in patients with CVD (RR = 0.90; 95% CI: 0.84-0.97; P = 0.005). In the stratified analysis, greater beneficial effects were observed in participants with a decrease in homocysteine concentrations of 25% or greater (RR = 0.85; 95% CI: 0.74-0.97; P = 0.03), those with a daily folate dose of less than 2mg (RR = 0.78; 95% CI: 0.68-0.89; P = 0.01), and populations in regions with no or partly fortified grain (RR = 0.87; 95% CI: 0.81-0.94; P = 0.04). Conclusions Our meta-analysis demonstrated that folic acid supplementation is effective in stroke prevention in patients with CVD.
- Subjects :
- Male
medicine.medical_specialty
Homocysteine
Disease
030204 cardiovascular system & hematology
Cochrane Library
Models, Biological
law.invention
03 medical and health sciences
chemistry.chemical_compound
Folic Acid
0302 clinical medicine
Randomized controlled trial
Risk Factors
law
Internal medicine
medicine
Humans
In patient
030212 general & internal medicine
Stroke
Aged
Randomized Controlled Trials as Topic
business.industry
General Medicine
Middle Aged
medicine.disease
Surgery
chemistry
Stroke prevention
Relative risk
Dietary Supplements
Female
business
Subjects
Details
- ISSN :
- 00029629
- Volume :
- 354
- Database :
- OpenAIRE
- Journal :
- The American Journal of the Medical Sciences
- Accession number :
- edsair.doi.dedup.....68d192f1a89fb6884d26ff41500dcf8d