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Immunodiagnostic Significance of Anti-RA33 Autoantibodies in Saudi Patients with Rheumatoid Arthritis
- Source :
- Journal of Immunology Research, Vol 2015 (2015), Journal of Immunology Research
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- The primary objective of this study was to evaluate and compare the immunodiagnostic significance and utility of anti-RA33 with anti-CCP, RF, and CRP in Saudi patients with rheumatoid arthritis.Methods. This was a prospective controlled clinical study conducted at King Abdul Aziz University Tertiary Medical Centre. The sera of 41 RA patients, 31 non-RA patients, and 29 healthy controls were collected. Anti-RA33 and anti-CCP were measured using commercially available ELISA principle kits. RF and CRP were measured using nephelometry.Results. Anti-RA33 antibodies had the lowest positive and negative predictive values and showed a sensitivity of 7.32% with 95.12% specificity. Of the other three markers (including anti-CCP antibodies, CRP, and RF), only anti-CCP showed specificity of 90.46% with sensitivity of 63.41% compared to non-RA patients + healthy control. There was a significant correlation with rheumatoid factor positivity with anti-CCP. With respect to CRP, a notable correlation was seen only with anti-RA33.Conclusion. Compared to rheumatoid factor, anti-CCP antibodies, and C-reactive proteins, the anti-RA33 autoantibodies seem to be not representing as an important additional immunodiagnostic marker in Saudi patients with established RA. RA33 may have more interest in early RA or less severe RA and other systemic connective tissue disorders.
- Subjects :
- Adult
Male
musculoskeletal diseases
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty
Article Subject
Immunology
Saudi Arabia
Arthritis
Immunologic Tests
Peptides, Cyclic
Gastroenterology
Arthritis, Rheumatoid
Rheumatoid Factor
Internal medicine
Positive predicative value
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
medicine
Humans
Immunology and Allergy
Rheumatoid factor
skin and connective tissue diseases
Autoantibodies
biology
business.industry
Autoantibody
General Medicine
Middle Aged
medicine.disease
C-Reactive Protein
Antibodies, Antinuclear
Immunoglobulin G
Rheumatoid arthritis
biology.protein
Female
Antibody
RA33
business
lcsh:RC581-607
Nephelometry
Biomarkers
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23147156 and 23148861
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....68bee416ae98c51387b075e75ad3719e