The Occurrence of Late Asthmatic Response to Exercise After Allergen Challenge

The determinants of late asthmatic responses to exercise remain unknown. It has been reported that they may develop in some adult subjects with asthma following a late asthmatic response to allergen.We intended to corroborate this finding in children with asthma and to investigate which aspect of airway responses to allergen is associated with late asthmatic responses to exercise.We studied 17 children with allergic asthma, who showed late asthmatic responses to inhaled allergen (Dermatophagoides pteronyssinus). Each underwent an exercise challenge test two days before (pre-allergen) and two days after (postallergen) an allergen inhalation challenge. FEV1 was measured at regular intervals up to ten hours after each challenge. Methacholine PC20 was measured before the allergen challenge and before the postallergen exercise challenge.After the pre-allergen exercise test, all the subjects showed isolated early asthmatic responses. After the postallergen exercise test, seven showed dual responses (early and late asthmatic responses) (group I) and the remaining ten showed isolated early asthmatic responses (group II). Bronchial responses to pre-allergen exercise or inhaled allergen and the severity of early asthmatic responses to postallergen exercise were similar in groups I and II. Neither before allergen inhalation nor before the postallergen exercise was methacholine PC20 different between the two groups. Methacholine dose shift caused by allergen challenge, however, was significantly greater in group I than in group II (-2.00+/-0.39 versus -1.36+/-0.53 doubling doses; P.05). There was significant correlation between the dose shift and the magnitude of late response to the postallergen exercise in the whole group (r = 0.51, P.05).Late asthmatic responses to exercise may develop in some children with asthma following a late asthmatic response to allergen. This phenomenon was related neither to the baseline nor to postallergen methacholine PC20 but to the extent of increased sensitivity to methacholine caused by allergen challenge.