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Effects of pudendal neuromodulation on bladder function in chronic spinal cord-injured rats
- Source :
- Journal of the Formosan Medical Association, Vol 115, Iss 9, Pp 703-713 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- Background/Purpose Few studies have investigated the feasibility of using pudendal neuromodulation to regulate bladder function in spinal cord-injured (SCI) animals. The present study aimed to determine the effects of electrical activation of the pudendal sensory branch on improving voiding functions in rats 6 weeks after a spinal cord injury and to explore the underlying neuromodulatory mechanisms. Methods Two urodynamic measurements were used to assess the effects of electrical stimulation (ES) on bladder and urethral functions: simultaneous recordings of the intravesical pressure (IVP) during continuous isotonic transvesical infusion (i.e., isotonic IVP) and external urethral sphincter (EUS) electromyography (EUS-EMG), and simultaneous recordings of transvesical pressure under isovolumetric conditions (i.e., isovolumetric IVP) and urethral perfusion pressure (UPP). Results Six weeks after the SCI, the rats showed voiding dysfunction, as indicated by abnormal cystometric measurements (e.g., increased volume threshold, increased contraction amplitude, and increased residual volume, and decreased voided volume). The voiding efficiency (VE) decreased to 13% after the SCI, but increased to 22–34% after applying pudendal afferent stimulation. In addition, pudendal stimulation significantly increased the EUS burst period and increased the difference between the UPP and the high-frequency oscillation (HFO) baselines, and changed the time offset between bladder and EUS activities. These findings suggest that pudendal afferent stimulation improved the VE by prolonging the micturition interval, decreased the urethral resistance, and recovered detrusor-sphincter dyssynergia during the voiding phase. Conclusion This study demonstrates the feasibility of using pudendal neuromodulation in chronic SCI rats. These results could aid in developing an advanced neural prosthesis to restore bladder function in clinical settings.
- Subjects :
- medicine.medical_specialty
media_common.quotation_subject
Pudendal nerve
030232 urology & nephrology
Urology
Urination
Electric Stimulation Therapy
voiding efficiency
Dyssynergia
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Urethra
medicine
Animals
electrical stimulation
Spinal cord injury
Spinal Cord Injuries
media_common
Medicine(all)
lcsh:R5-920
intravesical pressure
business.industry
Electromyography
Urethral sphincter
Urination disorder
General Medicine
pudendal nerve
medicine.disease
Urination Disorders
Neuromodulation (medicine)
spinal cord injury
Rats
Disease Models, Animal
Urodynamics
medicine.anatomical_structure
Anesthesia
Female
business
lcsh:Medicine (General)
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 09296646
- Volume :
- 115
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of the Formosan Medical Association
- Accession number :
- edsair.doi.dedup.....68ac7c278bec5c384e0192ba70546db6