Additional file 1: of Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Figure S1. Elevated transcript levels of cathepsins in aged Grn−/− mice. Figure S2. PGRN loss results in accumulation of LAMP1 and saposin D in MEF. Figure S3. Altered maturation of CatD and activity of cathepsins can be rescued by stable PGRN expression. Figure S4. PGRN, elastase digested PGRN and granulin E do not affect in vitro activity of cathepsins. Figure S5. Selectively enhanced CatD in vitro activity in non-microglial brain cells of aged Grn−/− mice. (PPTX 1753 kb)