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Optical coherence tomography angiography in the management of age-related macular degeneration
- Source :
- Current Opinion in Ophthalmology. 29:217-225
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- Optical coherence tomography angiography (OCT-A) provides rapid, flow-based imaging of the retinal and choroidal vasculature in a noninvasive manner. This review contrasts this novel technique with conventional angiography and discusses its current uses and limitations in the management of age-related macular degeneration (AMD).Initial work with OCT-A has focused on its ability to identify choriocapillaris flow alterations in dry AMD and to sensitively detect choroidal neovascular membranes (CNVs) in neovascular AMD. Reduced choriocapillaris flow beyond the borders of geographic atrophy seen on OCT-A suggests a primary vascular cause in geographic atrophy. Longitudinal OCT-A analysis of CNV morphology has demonstrated the transition from an immature to mature CNV phenotype following treatment. Current clinical applications of OCT-A include identification of asymptomatic CNV and monitoring for CNV development in the setting of an acquired vitelliform lesion.OCT-A remains a promising diagnostic tool but one still very much in evolution. Larger studies will be needed to more accurately describe its sensitivity and specificity for CNV detection and to better characterize longitudinal CNV morphologic changes. Anticipated hardware and software updates including swept-source light sources, automated montaging, and manual adjustment of interscan timing should enhance the capabilities of OCT-A in the management of AMD.
- Subjects :
- 0301 basic medicine
Novel technique
medicine.medical_specialty
Sensitivity and Specificity
Retina
Macular Degeneration
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Geographic Atrophy
Age related
medicine
Humans
Fluorescein Angiography
medicine.diagnostic_test
Choroid
business.industry
Retinal
General Medicine
Optical coherence tomography angiography
Macular degeneration
medicine.disease
Choroidal Neovascularization
eye diseases
Capillaries
Ophthalmology
030104 developmental biology
chemistry
Regional Blood Flow
Angiography
Wet Macular Degeneration
030221 ophthalmology & optometry
sense organs
Radiology
Tomography
business
Tomography, Optical Coherence
Coherence (physics)
Subjects
Details
- ISSN :
- 10408738
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Ophthalmology
- Accession number :
- edsair.doi.dedup.....68993303e4b01e644f9e0e8c65fa6afc