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MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer
- Source :
- Biochemical Pharmacology. 189:114357
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Pancreatic Cancer (PC) is a severe form of malignancy all over the world. Delayed diagnosis and chemoresistance are the major factors contributing to its poor prognosis and high mortality rate. The genetic and epigenetic regulations of biological pathways further complicate the progression and chemotherapy response to this cancer. MicroRNAs (MiRNAs) involvement has been observed in all types of cancers including PC. The understanding and categorization of miRNAs according to their specific targets are very important to develop early diagnostic and therapeutic interventions. The current review, emphasizing recent research findings, has categorized miRNAs that directly target the potential onco-factors that act as central converging signal-nodes in five major cancer-related pathways i.e., MAPK/ERK, JAK/STAT, Wnt/β-catenin, AKT/mTOR, and TGFβ in PC. The therapeutic perspectives of miRNAs in PC have also been discussed. This will help to understand the interplay of various miRNAs within foremost signaling pathways and develop a multifactorial approach to treat difficult-to-treat PC.
- Subjects :
- 0301 basic medicine
MAP Kinase Signaling System
Biochemistry
stat
03 medical and health sciences
0302 clinical medicine
Pancreatic cancer
microRNA
Animals
Humans
Medicine
Epigenetics
Protein kinase B
PI3K/AKT/mTOR pathway
Pharmacology
business.industry
TOR Serine-Threonine Kinases
Wnt signaling pathway
Cancer
medicine.disease
Pancreatic Neoplasms
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Gene Targeting
Cancer research
Inflammation Mediators
business
Signal Transduction
Subjects
Details
- ISSN :
- 00062952
- Volume :
- 189
- Database :
- OpenAIRE
- Journal :
- Biochemical Pharmacology
- Accession number :
- edsair.doi.dedup.....6894ccd8ece62097e2977a0004490c7a