Localization of epileptic foci by means of cortical imaging using a spherical head model

We have applied a cortical imaging technique (CIT) with a three-sphere head model to estimate cortical potentials from scalp electroencephalogram (EEG) recordings during interictal spikes in a pediatric epilepsy patient. The CIT analysis was performed during the ascending limb of interictal spikes and localized areas of activity were observed, overlying the epileptogenic zone, as being confirmed by the electrocorticography recordings and neurosurgical resections of the patient. The present study suggests that CIT may become a useful alternative for noninvasive localization of intracranial sources generating epileptiform activity from pre-operative scalp EEG recordings.