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Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Egyptian spiny mice are the only known species to have human-like menstruation and a postpartum ovulation. Unfortunately, no endocrine or morphological evidence has been provided for a postpartum ovulation in spiny mice, and while later stages of pregnancy have been well studied, early events including embryo implantation and spiral artery remodelling have not been reported. This study compared the sex steroid endocrinology and reproductive tract morphology of dams at eight timepoints (n = 40) postpartum to determine the timing of ovulation and the timing and invasiveness of embryo implantation in A. cahirinus. Reproductive tracts were fixed and stained for histology and immunohistochemistry, and plasma was prepared for enzyme-linked immunosorbent assay. Ovarian histology and estradiol-17B concentrations indicate ovulation within 48 h of parturition and then immediate resumption of follicular growth. Uterine histology and immunohistochemistry revealed progressive epithelial repair, endometrial growth and spiral artery assembly and remodelling in dams postpartum. Blastocysts were seen in the uterine lumen at day 4–5 postpartum and embryos had implanted superficially with minimal stromal invasion by day 5–6. This study provides further evidence for the unique, humanesque reproductive biology of spiny mice and for a postpartum ovulation using endocrine and morphological changes observed during early pregnancy. Taken together, our data suggest that spiny mice may act as appropriate models of human pregnancy disorders such as implantation failure or pre-eclampsia.
- Subjects :
- Ovulation
0301 basic medicine
Cell biology
Spiral artery
Science
media_common.quotation_subject
Physiology
Endometrium
Article
03 medical and health sciences
Medical research
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Developmental biology
Follicular phase
Reproductive biology
medicine
Animals
Endocrine system
reproductive and urinary physiology
media_common
030219 obstetrics & reproductive medicine
Multidisciplinary
biology
Postpartum Period
biology.organism_classification
medicine.disease
Menstruation
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Spiny mouse
Medicine
Female
Murinae
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....687f721111833f4cd0e1d8fa683b9c96