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DHA Protects Against Zinc Mediated Alterations in Neuronal Cellular Bioenergetics
- Source :
- Cellular Physiology and Biochemistry. 28:157-162
- Publication Year :
- 2011
- Publisher :
- S. Karger AG, 2011.
-
Abstract
- Zinc accumulation may impair cellular bioenergetics, which is associated with neuronal apoptosis. We simultaneously assessed anaerobic and aerobic metabolism in live cells to characterise this effect and hypothesised that the omega 3 fatty acid docosahexaenoic acid (DHA) would protect against any zinc mediated alterations in bioenergetics. In this study we observed a decrease in cellular oxygen consumption, but not glycolytic rate, following chronic zinc exposure, which was specific for neuronal cells. This was due to impaired ATP turnover, without any other effects on mitochondrial function, and was restored by DHA. DHA had no further effects on bioenergetics. These data suggest that zinc disrupts bioenergetics at a point distal to the respiratory chain, which is restored by DHA.
- Subjects :
- Keratinocytes
Neurons
Docosahexaenoic Acids
Bioenergetics
Physiology
Cellular respiration
Respiratory chain
chemistry.chemical_element
Zinc
Biology
Cell Line
Mitochondria
Cell biology
Adenosine Triphosphate
Oxygen Consumption
chemistry
Biochemistry
Docosahexaenoic acid
Humans
Glycolysis
Energy Metabolism
Omega 3 fatty acid
Anaerobic exercise
Subjects
Details
- ISSN :
- 14219778 and 10158987
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Cellular Physiology and Biochemistry
- Accession number :
- edsair.doi.dedup.....6870f739405e43fef91e84778ff15e87