Alkylation of 2-Phenyl-4-quinolones: Synthetic and Structural Studies

Authors :: Anne-Marie Mariotte
Mohamed Hadjeri
Ahcène Boumendjel
Département de pharmacochimie moléculaire (DPM)
Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)
Source :: Chem. Pharm. Bull., Chem. Pharm. Bull., 2001, 49, pp.1352-1355
Publication Year :: 2001
Publisher :: Pharmaceutical Society of Japan, 2001.
Abstract: The alkylation of 2-phenyl-4-quinolones was investigated and showed that the N-alkylation versus O-alkylation is highly dependent on whether C-5 is hydroxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and the NMR structural studies are reported.

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