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Towards better understanding of giant cell granulomas of the oral cavity
- Source :
- Journal of Clinical Pathology. 74:483-490
- Publication Year :
- 2021
- Publisher :
- BMJ, 2021.
-
Abstract
- Giant cell granulomas are enigmatic lesions of the oral cavity characterised by a peculiar combined proliferation of mononuclear and multinucleated giant cells in a mesenchymal stromal background. Central and peripheral giant cell granulomas may have similar pathogenesis and histology but differ in their location and biological behaviour. It is important to differentiate them from other giant cell lesions that can occur in the oral cavity, such as giant cell tumour of the bone, aneurysmal bone cyst, brown tumour of hyperparathyroidism, and giant cell lesions of Ramon syndrome, Noonan syndrome, neurofibromatosis and Jaffe-Campanacci syndrome. A recent insight into their molecular genetics and pathogenesis, with identification of KRAS, FGFR1 and TRPV4 mutations, allows for better diagnostic differentiation and opens the door to the use of pathway inhibitors in the treatment of recurrent or dysmorphic lesions. In this review, we provide an updated summary of the clinical and pathological features of oral cavity giant cell granulomas that help with their precise diagnosis and management.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Stromal cell
Adolescent
Biopsy
Giant Cells
Immunophenotyping
Pathology and Forensic Medicine
Diagnosis, Differential
Pathogenesis
Young Adult
03 medical and health sciences
0302 clinical medicine
Granuloma, Giant Cell
Predictive Value of Tests
medicine
Humans
Genetic Predisposition to Disease
Neurofibromatosis
Child
Aged
Cell Proliferation
Mouth
business.industry
Mesenchymal stem cell
030206 dentistry
General Medicine
Aneurysmal bone cyst
Middle Aged
medicine.disease
Phenotype
Giant cell
Child, Preschool
030220 oncology & carcinogenesis
Granuloma
Mutation
Noonan syndrome
Female
Mouth Diseases
business
Subjects
Details
- ISSN :
- 14724146 and 00219746
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....68612cbfc7fa2a0fcd9f3e9a4f063b1d