1152. Characteristics of Patients with Invasive Infections Caused by Trichosporon asahii

Background Trichosporon asahii is main species for invasive infection by genus Trichosporon. There has been few data regarding the incidence, clinical characteristics, and treatment outcomes of T. asahii colonization and invasive infection. Methods We retrospectively reviewed the microbiological records of patients whose culture results were positive for T. asahii, from a tertiary hospital in South Korea between January 2009 and July 2018. Invasive disease was defined according to the consensus statement of the Invasive Fungal Infections Cooperative Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group (EORTC-MSG). Results During the study period, a total of 259 clinical T. asahii isolates (137 urine, 55 respiratory specimen, 26 blood, 16 surgical site drainage, 9 tissue biopsy, 9 open discharge, 3 toe/nail, 2 pleural fluid and 2 stool) were collected from 102 patients. Of the 102 patients, 18 (18%) had invasive infection: fungemia (12 [67%]), complicated skin and soft tissue infection (3 [17%]), pneumonia with or without empyema (2 [11%]), and complicated intra-abdominal infection (1 [5%]). Invasive infection was associated with hematologic malignancy (33% vs. 7%, P=0.006), end stage renal disease requiring dialysis (28% vs. 7%, P=0.02), indwelling central venous catheter (94% vs. 54%, P =0.001), and prior antifungal agent use (50% vs. 18%, P=0.01). Invasive group had significantly higher in-hospital mortality than non-invasive group (61% vs. 27%, P = 0.006). Characteristics of 102 patients with invasive and non-invasive Trichosporon asahii disease Conclusion Invasive infection was associated with hematologic malignancy, end stage renal disease, indwelling of central venous catheter, and prior antifungal agent use, and high mortality up to 60%. Those with above risk factors should be monitored for development of invasive T. asahii infection. Disclosures All Authors: No reported disclosures