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Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents
- Source :
- Archives of Toxicology. 81:627-639
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- The organophosphorus nerve agents sarin, soman, cyclosarin and tabun phosphylate a tyrosine residue on albumin in human blood. These adducts may offer relatively long-lived biological markers of nerve agent exposure that do not 'age' rapidly, and which are not degraded by therapy with oximes. Sensitive methods for the detection of these adducts have been developed using liquid chromatography-tandem mass spectrometry. Adducts of all four nerve agents were detected in the blood of exposed guinea pigs being used in studies to improve medical countermeasures. The tyrosine adducts with soman and tabun were detected in guinea pigs receiving therapy 7 days following subcutaneous administration of five times the LD(50) dose of the respective nerve agent. VX also forms a tyrosine adduct in human blood in vitro but only at high concentrations.
- Subjects :
- Cholinesterase Reactivators
Sarin
medicine.medical_specialty
Health, Toxicology and Mutagenesis
Guinea Pigs
Cyclosarin
Poison control
Pharmacology
Toxicology
chemistry.chemical_compound
Organophosphorus Compounds
Albumins
Oximes
Soman
medicine
Animals
Humans
Chemical Warfare Agents
Tyrosine
Tabun
Nerve agent
Albumin
General Medicine
Surgery
chemistry
Biomarkers
Protein Binding
medicine.drug
Subjects
Details
- ISSN :
- 14320738 and 03405761
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Archives of Toxicology
- Accession number :
- edsair.doi.dedup.....685710a3395f4229a27b883eaf472110