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JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma
- Source :
- Neuro-Oncology. 16:1229-1243
- Publication Year :
- 2014
- Publisher :
- Oxford University Press (OUP), 2014.
-
Abstract
- Glioblastoma (GBM) is an aggressive, highly invasive, vascularized tumor with a long-term survival of
- Subjects :
- STAT3 Transcription Factor
Cancer Research
Mice, Nude
Antineoplastic Agents
Receptor tyrosine kinase
Mice
Cell Line, Tumor
Animals
Humans
Neoplasm Invasiveness
Epidermal growth factor receptor
Enzyme Inhibitors
Protein kinase B
PI3K/AKT/mTOR pathway
Focal Adhesions
biology
Brain Neoplasms
Janus Kinase 2
Tyrphostins
ErbB Receptors
Oncology
Tumor progression
Basic and Translational Investigations
biology.protein
Cancer research
Neurology (clinical)
Signal transduction
Glioblastoma
Tyrosine kinase
Signal Transduction
Proto-oncogene tyrosine-protein kinase Src
Subjects
Details
- ISSN :
- 15235866 and 15228517
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Neuro-Oncology
- Accession number :
- edsair.doi.dedup.....6849257e8915d3205e97915bcdeb024a