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Delta Lactate (Three-hour Lactate Minus Initial Lactate) Prediction of In-hospital Death in Sepsis Patients
- Source :
- Cureus
- Publication Year :
- 2020
-
Abstract
- This study examines the relationship between serial serum lactate levels and in-hospital mortality in an adult cohort of emergency department patients with severe sepsis or septic shock. Of the 164 patients in the cohort, 130 also got three-hour lactate in addition to the initial one. The median initial lactate was 3.01 (interquartile range [IQR]: 1.71-4.62). The median repeat lactate was 2.58 (IQR: 1.4-3.9). The in-hospital death rate was 23% for men and 29% for women. The delta lactate was significantly higher in women (P=0.0070), driven by a lower initial lactate (P=0.0277). In a multivariate regression model controlled for age and gender, a statistically significant correlation was noted between an increase in the delta lactate and in-hospital death (P=0.0323; R2=11.3%). The results of this single-center study suggest that an increase in serum lactic acid is significantly associated with higher in-hospital death.
- Subjects :
- In hospital death
medicine.medical_specialty
lactate
Septic shock
business.industry
Mortality rate
General Engineering
Infectious Disease
Emergency department
030204 cardiovascular system & hematology
medicine.disease
Lactic acid
Sepsis
sepsis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
chemistry
Interquartile range
Internal medicine
Cohort
medicine
Emergency Medicine
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 21688184
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cureus
- Accession number :
- edsair.doi.dedup.....6843ea722b9551d3358e89e35522285d