Back to Search
Start Over
Regulation of aberrantly expressed SERPINH1 by antitumor miR-148a-5p inhibits cancer cell aggressiveness in gastric cancer
- Source :
- Journal of human genetics. 65(8)
- Publication Year :
- 2020
-
Abstract
- RNA-sequencing-based microRNA (miRNA) expression signatures have revealed that miR-148a-5p (the passenger strand of the miR-148a-duplex) is downregulated in various kinds of cancer tissues. Analysis of The Cancer Genome Atlas (TCGA) database showed that low expression of miR-148a-5p was predictive of a lower survival rate (p = 0.041) in patients with gastric cancer (GC). Downregulation of miR-148a-5p was confirmed in GC clinical specimens, and its ectopic expression attenuated GC cell proliferation. Our search for miRNA target genes identified a total of 18 oncogenic targets of miR-148a-5p in GC cells. Among these targets, high expression levels of six genes (THBS2, P4HA3, SERPINH1, CDH11, BCAT1, and KCNG3) were closely associated with a poor prognosis (10-year survival rates) in GC patients (p
- Subjects :
- 0301 basic medicine
Small interfering RNA
Procollagen-Proline Dioxygenase
Down-Regulation
030105 genetics & heredity
Biology
03 medical and health sciences
Downregulation and upregulation
Stomach Neoplasms
Cell Line, Tumor
microRNA
Databases, Genetic
Genetics
Humans
RNA-Induced Silencing Complex
RNA, Small Interfering
Gene
HSP47 Heat-Shock Proteins
Genetics (clinical)
Transaminases
Cell Proliferation
Gene knockdown
Cell growth
Gene Expression Profiling
Cadherins
Prognosis
Gene Expression Regulation, Neoplastic
Survival Rate
MicroRNAs
030104 developmental biology
Potassium Channels, Voltage-Gated
Gene Knockdown Techniques
Cancer cell
Cancer research
Ectopic expression
Thrombospondins
Subjects
Details
- ISSN :
- 1435232X
- Volume :
- 65
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of human genetics
- Accession number :
- edsair.doi.dedup.....683856588ac569002072443e460d840b