Synthesis of new 6-halogeno-imidazo[1,2-a]pyridines by SRN1 reactions

Authors :: Maxime D. Crozet
Caroline Castera
Michel P. Crozet
Patrice Vanelle
Mustapha Kaafarani
Chimie, biologie et radicaux libres - UMR 6517 (CBRL)
Université de la Méditerranée - Aix-Marseille 2-Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS)
Institut de Chimie Radicalaire (ICR)
Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Source :: ARKIVOC, Vol 2003, Iss 10, Pp 273-282 (2003), ARKIVOC-Online Journal of Organic Chemistry, ARKIVOC-Online Journal of Organic Chemistry, Arkat USA Inc, 2003, ARKIVOC, 2003 (x), pp.273-282. ⟨10.3998/ark.5550190.0004.a26⟩, ARKIVOC-Online Journal of Organic Chemistry, 2003, ARKIVOC, 2003 (x), pp.273-282. ⟨10.3998/ark.5550190.0004.a26⟩
Publication Year :: 2003
Publisher :: Arkat USA, Inc., 2003.
Abstract: International audience; New 2-chloromethyl-6-halogeno-imidazo[1,2-a]pyridines and 2-chloromethyl-6-halogeno-3-nitroimidazo[1,2-a]pyridines were prepared and reacted under experimental conditions of S RN 1 reactions with different sulfur and carbon centered nucleophiles to give new 6-halogeno-2-substituted-imidazo[1,2-a]pyridines and 6-halogeno-3-nitro-2-substituted-imidazo[1,2-a] pyridines in good yields. Only the chloromethyl group was found to be reactive under these experimental conditions.

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