A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:48:43Z No. of bitstreams: 1 S0100-40422008000500030.pdf: 128031 bytes, checksum: 364a0b8e7522920f7d669b2e293d6399 (MD5) Made available in DSpace on 2013-08-22T18:48:43Z (GMT). No. of bitstreams: 1 S0100-40422008000500030.pdf: 128031 bytes, checksum: 364a0b8e7522920f7d669b2e293d6399 (MD5) Previous issue date: 2008-01-01 Made available in DSpace on 2013-09-30T19:38:45Z (GMT). No. of bitstreams: 2 S0100-40422008000500030.pdf: 128031 bytes, checksum: 364a0b8e7522920f7d669b2e293d6399 (MD5) S0100-40422008000500030.pdf.txt: 41358 bytes, checksum: 172a45810dd4c57e4d49eaada1700ca1 (MD5) Previous issue date: 2008-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:17:29Z No. of bitstreams: 2 S0100-40422008000500030.pdf: 128031 bytes, checksum: 364a0b8e7522920f7d669b2e293d6399 (MD5) S0100-40422008000500030.pdf.txt: 41358 bytes, checksum: 172a45810dd4c57e4d49eaada1700ca1 (MD5) Made available in DSpace on 2014-05-20T14:17:29Z (GMT). No. of bitstreams: 2 S0100-40422008000500030.pdf: 128031 bytes, checksum: 364a0b8e7522920f7d669b2e293d6399 (MD5) S0100-40422008000500030.pdf.txt: 41358 bytes, checksum: 172a45810dd4c57e4d49eaada1700ca1 (MD5) Previous issue date: 2008-01-01 NIH (National Institutes of Health) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites. Universidade de São Paulo Instituto de Química de São Carlos Universidade Federal de São Carlos (UFSCar) Departamento de Ecologia e Biologia Evolutiva Universidade Estadual Paulista Departamento de Bioquímica e Tecnologia Química Universidade Estadual Paulista Centro de Estudos Ambientais Faculdade de Ciências de Lisboa Centro de Biologia Ambiental Departamento de Biologia Vegetal (Microbiologia) Universidade Federal do Ceará (UFC) Departamento de Fisiologia e Farmacologia Universidade Metodista de Piracicaba Faculdade de Ciências da Saúde Instituto Butantan Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Bioquímica e Imunologia Universidade de São Paulo Instituto de Física de São Carlos Universidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas Divisão de Recursos Microbianos Universidade Estadual Paulista Departamento de Bioquímica e Tecnologia Química Universidade Estadual Paulista Centro de Estudos Ambientais