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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 23:5014-5021
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1,5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed. Download : Download full-size image
- Subjects :
- Models, Molecular
Stereochemistry
Clinical Biochemistry
information science
Pharmaceutical Science
Antineoplastic Agents
Crystallography, X-Ray
Biochemistry
Mice
Structure-Activity Relationship
Mouse xenograft
Neoplasms
Drug Discovery
Animals
Humans
Structure–activity relationship
natural sciences
Molecular Biology
Amitrole
Chemistry
Organic Chemistry
Janus Kinase 2
Triazoles
Ligand (biochemistry)
Pyrimidines
Molecular Medicine
Triazolopyridine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....681fd99055683a4b0d3829fed9eaeb2f
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.06.008