Myeloid ecotropic viral integration site 1 inhibits cell proliferation, invasion or migration in human gastric cancer

// Fei Song 1 , Hong Wang 1 and Yingying Wang 2 1 Department of General Surgery, Shandong Provincial Third Hospital, Jinan, Shandong, China 2 Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China Correspondence to: Yingying Wang, email: wangyingyingsdszz@163.com Keywords: MEIS1, gastric cancer, proliferation, invasion, migration Received: June 27, 2017 Accepted: September 05, 2017 Published: September 28, 2017 ABSTRACT Myeloid ecotropic viral integration site 1 (MEIS1) has been identified to be a potential tumor suppressor in some cancers. However, the mechanisms underlying MEIS1-induced cancer development and progression were not clear. Here, we investigated the expression and role of MEIS1 in gastric cancer. In vivo , we analyzed tumor growth using nude mice model. In the present study, MEIS1 expression was obviously decreased in GC cell lines compared with that in normal gastric cell lines (all p