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Increased levels of soluble complement receptor 1 in serum of patients with liver diseases
- Source :
- Hepatology. 24:118-122
- Publication Year :
- 1996
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1996.
-
Abstract
- Complement receptor type 1 (CR1) is an integral membrane protein of many hematopoietic cells and is found in a soluble form in plasma. Preliminary data have indicated that soluble complement receptor 1 (sCR1) levels in serum were increased in patients with cirrhosis. In this study, sCR1 was measured in patients with various liver diseases with a newly established enzyme-linked immunosorbent assay (ELISA). sCR1 level was elevated in chronic active hepatitis C (24 patients, 62.6 +/- 31 ng/ML; 31 normal controls, 31.4 +/- 7.8 ng/mL, P.001), and in cirrhosis (35 patients, 143.7 +/- 61 ng/mL, P.001). The levels increased transiently in 3 patients who had amanita phalloides intoxication. In 25 patients with advanced cirrhosis (pretransplantation screening), there were significant inverse correlations between sCR1 and both the prothrombin index (rs = -.60, P.002) and the aminopyrine breath test (rs = -.51, P.01). Following liver transplantation, the levels dropped from 166 +/- 70 to 49 +/- 24 ng/mL (P.0001), and serial measurements in the posttransplantation period showed a correlation with liver dysfunction, regardless of etiology. Since CR1 is not produced by hepatocytes, the most likely explanation for the increased level of sCR1 is reduced is reduced catabolism. Thus, sCR1 may be added to the short list of large glycoproteins that accumulate in liver disease.
- Subjects :
- Liver Cirrhosis
medicine.medical_specialty
Cirrhosis
Amanita
Complement receptor 1
Enzyme-Linked Immunosorbent Assay
Mushroom Poisoning
Complement Receptor Type 1
Reference Values
Internal medicine
medicine
Humans
In patient
Aminopyrine
Receptor
Integral membrane protein
chemistry.chemical_classification
Hepatology
biology
business.industry
Liver Diseases
Hepatitis B
medicine.disease
Hepatitis C
Complement C7
Complement C6
Liver Transplantation
Receptors, Complement
Haematopoiesis
Endocrinology
chemistry
biology.gene
Glycoprotein
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 15273350 and 02709139
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Hepatology
- Accession number :
- edsair.doi.dedup.....6804723212bd2186f87ad159db8e1daf