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Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies
- Source :
- Journal of Clinical Medicine, Vol 9, Iss 1, p 282 (2020), Journal of Clinical Medicine
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Degenerative cervical myelopathy (DCM) is estimated to be the most common cause of adult spinal cord impairment. Evidence that is suggestive of a genetic basis to DCM has been increasing over the last decade. A systematic search was conducted in MEDLINE, EMBASE, Cochrane, and HuGENet databases from their origin up to 14th December 2019 to evaluate the role of single genes in DCM in its onset, clinical phenotype, and response to surgical intervention. The initial search yielded 914 articles, with 39 articles being identified as eligible after screening. We distinguish between those contributing to spinal column deterioration and those contributing to spinal cord deterioration in assessing the evidence of genetic contributions to DCM. Evidence regarding a total of 28 candidate genes was identified. Of these, 22 were found to have an effect on the radiological onset of spinal column disease, while 12 genes had an effect on clinical onset of spinal cord disease. Polymorphisms of eight genes were found to have an effect on the radiological severity of DCM, while three genes had an effect on clinical severity. Polymorphisms of six genes were found to have an effect on clinical response to surgery in spinal cord disease. There are clear genetic effects on the development of spinal pathology, the central nervous system (CNS) response to bony pathology, the severity of both bony and cord pathology, and the subsequent response to surgical intervention. Work to disentangle the mechanisms by which the genes that are reviewed here exert their effects, as well as improved quality of evidence across diverse populations is required for further investigating the genetic contribution to DCM.
- Subjects :
- Candidate gene
Cord
Central nervous system
severity
lcsh:Medicine
Review
Disease
Bioinformatics
surgery
03 medical and health sciences
Myelopathy
0302 clinical medicine
single nucleotide polymorphism
Medicine
genetics
business.industry
lcsh:R
ossification posterior longitudinal ligament
General Medicine
Spinal cord
medicine.disease
Spinal column
3. Good health
medicine.anatomical_structure
030220 oncology & carcinogenesis
Meta-analysis
degenerative cervical myelopathy
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....67fc496f646541961642549da2cf526f