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CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency
- Source :
- Journal of Virology. 78:6055-6060
- Publication Year :
- 2004
- Publisher :
- American Society for Microbiology, 2004.
-
Abstract
- LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
- Subjects :
- Immunology
Mice, Transgenic
chemical and pharmacologic phenomena
Microbiology
Mice
Retrovirus
Downregulation and upregulation
Murine Acquired Immunodeficiency Syndrome
Virology
medicine
Animals
CD40 Antigens
CD154
Immunodeficiency
TNF Receptor-Associated Factor 6
Binding Sites
CD40
biology
Hypergammaglobulinemia
Proteins
hemic and immune systems
biology.organism_classification
medicine.disease
Insect Science
biology.protein
Pathogenesis and Immunity
Tumor necrosis factor alpha
CD80
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....67f8e70790085951b6268f1b7621716f