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Suicidality and self-injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing
- Source :
- Sørensen, J Ø, Rasmussen, A, Roesbjerg, T, Verhulst, F C & Pagsberg, A K 2022, ' Suicidality and self-injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing ', Acta Psychiatrica Scandinavica, vol. 145, no. 2, pp. 209-222 . https://doi.org/10.1111/acps.13360
- Publication Year :
- 2022
-
Abstract
- Objective Meta-analyses have established a heightened risk of suicidality for youth treated with selective serotonin reuptake inhibitors (SSRIs). The present study investigates the risk and possible predictors of suicidality and non-suicidal self-injury (NSSI) associated with SSRI treatment in a clinical sample of children and adolescents. Methods An observational, longitudinal, retrospective study using a within-subject study design including in- and outpatients aged 0-17 years treated with SSRIs. Data were obtained from digital medical records and prescription software. Results N=365 patients were included (64.1, mean [SD] age 14.5 [2.04] years, with primarily depression, anxiety or obsessive-compulsive disorder. No suicides occurred. When comparing the six-week period immediately prior to versus following SSRI initiation, the patient proportion with broadly defined suicidality decreased (38.54.2 ptextless0.001) while the proportion with suicide attempts was stable (2.8.8 p=1.000). The proportion with NSSI decreased statistically non-significantly (12.4.4 p=0.067). Results from individually standardized observation periods were similar, however the proportion with suicide attempts decreased statistically non-significantly and the proportion with NSSI decreased significantly. Suicidality during SSRI treatment was associated with previous suicidality (OR[CI]=6.0 [2.4-14.8], ptextless0.001), depression as indication for SSRI treatment (OR[CI]=2.1 [1.2-3.7], p=0.01), female sex (OR[CI]=2.1 [1.1-4.1], p=0.02), and previous NSSI (OR[CI]=2.0 [1.2-3.5], p=0.01). Conclusion Suicidality was common in youth treated with SSRIs. The patient proportion with overall suicidality decreased and the proportion with attempted suicide was stable in the weeks following SSRI initiation. Previous suicidality, depression, female sex, and previous NSSI are important predictors for suicidality during SSRI treatment in youth. Objective Meta-analyses have established a heightened risk of suicidality for youth treated with selective serotonin reuptake inhibitors (SSRIs). The present study investigates the risk and possible predictors of suicidality and non-suicidal self-injury (NSSI) associated with SSRI treatment in a clinical sample of children and adolescents. Methods An observational, longitudinal, retrospective study using a within-subject study design including in- and outpatients aged 0–17 years treated with SSRIs. Data were obtained from digital medical records and prescription software. Results N = 365 patients were included (64.1% female), mean (SD) age 14.5 (2.04) years, with primary depression, anxiety or obsessive-compulsive disorder. No suicides occurred. When comparing the 6-week period immediately prior to versus following SSRI initiation, the patient proportion with broadly defined suicidality decreased (38.5% vs. 24.2%, p < 0.001) while the proportion with suicide attempts was stable (2.8% vs. 2.8%, p = 1.000). The proportion with NSSI decreased statistically non-significantly (12.4% vs. 8.4%, p = 0.067). Results from individually standardized observation periods were similar; however, the proportion with suicide attempts decreased statistically non-significantly and the proportion with NSSI decreased significantly. Suicidality during SSRI treatment was associated with previous suicidality (OR[CI] = 6.0 [2.4–14.8], p < 0.001), depression as indication for SSRI treatment (OR[CI] = 2.1 [1.2–3.7], p = 0.01), female sex (OR[CI] = 2.1 [1.1–4.1], p = 0.02) and previous NSSI (OR[CI] = 2.0 [1.2–3.5], p = 0.01). Conclusion Suicidality was common in youth treated with SSRIs. The patient proportion with overall suicidality decreased, and the proportion with attempted suicide was stable in the weeks following SSRI initiation. Previous suicidality, depression, female sex and previous NSSI are important predictors for suicidality during SSRI treatment in youth.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
suicidality
Suicidal Ideation
antidepressive agents
Internal medicine
Medicine
Humans
adolescents
Medical prescription
Child
Children
Depression (differential diagnoses)
Retrospective Studies
non-suicidal self-injury
business.industry
Medical record
serotonin reuptake inhibitors
Female sex
Retrospective cohort study
Serotonin reuptake
Psychiatry and Mental health
Suicide
Anxiety
Observational study
Female
medicine.symptom
business
Self-Injurious Behavior
Selective Serotonin Reuptake Inhibitors
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Sørensen, J Ø, Rasmussen, A, Roesbjerg, T, Verhulst, F C & Pagsberg, A K 2022, ' Suicidality and self-injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing ', Acta Psychiatrica Scandinavica, vol. 145, no. 2, pp. 209-222 . https://doi.org/10.1111/acps.13360
- Accession number :
- edsair.doi.dedup.....67de706624e0f7b5471f6071972ac26a