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Effect of Beta-Blocker on Left Ventricular Function and Natrituretic Peptides in Patients With Chronic Heart Failure Treated With Angiotensin-Converting Enzyme Inhibitor
- Source :
- Japanese Circulation Journal. 64:365-369
- Publication Year :
- 2000
- Publisher :
- Japanese Circulation Society, 2000.
-
Abstract
- To evaluate whether or not beta-blockers can improve the condition of patients with heart failure treated with a combination of diuretics, digitalis and angiotensin-converting enzyme inhibitor (ACEI), 52 patients with chronic heart failure who have been treated with ACEI for more than 6 months were enrolled. They were divided into 2 groups: 26 patients continued the same therapy another 6 months or more (group A), and 26 patients were given oral metoprolol for 6 months or more, in addition to the ACEI (group B). Echocardiographic parameters and atrial and brain natriuretic peptides (ANP, BNP) were measured. The left ventricular dimensions at end-diastole and end-systole were significantly decreased and fractional shortening was significantly increased in group B after 6 months' treatment with the beta-blocker, but these parameters remained unchanged in group A. Plasma levels of both ANP and BNP were significantly decreased in group B, but remained unchanged in group A. These results indicate that concomitant beta-blocker therapy can improve left ventricular function and attenuate plasma ANP and BNP levels in patients with chronic heart failure treated with ACEI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Heart disease
Physiology
medicine.drug_class
Adrenergic beta-Antagonists
Angiotensin-Converting Enzyme Inhibitors
Ventricular Function, Left
Atrial natriuretic peptide
Internal medicine
Natriuretic Peptide, Brain
Natriuretic peptide
medicine
Humans
cardiovascular diseases
Diuretics
Beta blocker
Metoprolol
Heart Failure
Digitalis
Plants, Medicinal
biology
business.industry
Hemodynamics
Angiotensin-converting enzyme
Middle Aged
medicine.disease
Brain natriuretic peptide
Plants, Toxic
Echocardiography
Heart failure
cardiovascular system
biology.protein
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Atrial Natriuretic Factor
hormones, hormone substitutes, and hormone antagonists
Phytotherapy
medicine.drug
Subjects
Details
- ISSN :
- 13474839 and 00471828
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Japanese Circulation Journal
- Accession number :
- edsair.doi.dedup.....67dd2a6b40663e857f23aabb8c7e028c