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Anodal tDCS increases corticospinal output and projection strength in multiple sclerosis
- Source :
- Neuroscience letters. 554
- Publication Year :
- 2013
-
Abstract
- The application of anodal transcranial direct current stimulation (atDCS) to the human brain has been shown to elicit corticospinal (CS) excitability changes. This study evaluated the effect of a single session of atDCS on CS excitability in patients with multiple sclerosis (MS). atDCS and sham tDCS (stDCS) were applied to the primary motor cortex (M1) contralateral to the more severely impaired hand for 20min in a double-blinded crossover design. Changes in CS excitability were assessed using transcranial magnetic stimulation (TMS). The area under the recruitment curves increased significantly after application of atDCS (+56.58%, p=0.023) but not after stDCS. A sigmoidal curve-analysis revealed a higher plateau of the curve after atDCS (+22.2%, p0.001). Our results showed that atDCS over M1 has the ability to increase CS output and projection strength in MS-patients, suggesting that atDCS can be considered during neural rehabilitation to facilitate motor recovery in MS.
- Subjects :
- Adult
Male
Anodal tdcs
Multiple Sclerosis
medicine.medical_treatment
Electric Stimulation Therapy
Double-Blind Method
medicine
Humans
In patient
Electrodes
Aged
Cross-Over Studies
Transcranial direct-current stimulation
General Neuroscience
Multiple sclerosis
Brain
Human brain
Middle Aged
medicine.disease
Crossover study
Transcranial magnetic stimulation
medicine.anatomical_structure
Spinal Cord
Female
Primary motor cortex
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 18727972
- Volume :
- 554
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....67cbc2a4a6ee2d05a25023b94cd0fca5